Now in early access

Stop repeating
failed experiments.

Synes helps researchers learn from prior experimental attempts and design better experiments faster.

app.synes.io / experiments
Synes
Workspace
Experiments
History
Parameters
Analytics
Discovery
Search
Insights
3 NEW INSIGHTS
Pattern detected in
pH trials
Experiment Log
All
Completed
Failed
Running
ID Experiment Outcome pH Temp (°C) Yield Trend
#EX-041 Protein folding — buffer B Success 7.4 37° 82%
#EX-040 Protein folding — buffer A Failed 6.8 37° 18%
#EX-039 Cell culture — substrate C Partial 7.0 35° 54%
#EX-038 CRISPR edit — target locus 7 Failed 7.2 37° 9%
#EX-037 Enzyme assay — variant D Running 7.5 38°
Experiment Insights
Success Rate
34%
+12% vs last 30 days
Parameter Comparison
pH level 7.4 optimal
Temperature 37°C range
Buffer conc. 50 mM
Incubation 24 hr
Pattern Detected
Experiments with pH > 7.2 at 37°C show 3.4× higher yield in protein folding trials.
Similar Experiments Found
12
Across 4 research groups

Most experimental knowledge is lost.

Failed experiments rarely make it into publications. As a result, researchers across labs unknowingly repeat the same unsuccessful approaches — wasting time, resources, and momentum.

50–70% of experiments yield negative results that go unreported
Lab notebooks stay siloed, never searchable across teams
Redundant work costs the research sector billions annually
Exp #EX-027
Protocol: A-variant
pH: 6.5
Yield: 11%
Failed — not published
Lab Notebook — 2022
Condition: Low temp
Result: Inconclusive
Unpublished
Exp #EX-031
Buffer: PBS
pH: 6.8
Yield: 8%
Failed — not published
Exp #EX-019
Team: Lab B
Same params as #027
Repeated failure
Pilot Study — Q3
Approach: A-variant
Outcome: Failed
Internal only
↻ Same approach tried again — unknown to researchers

Turn experimental history into discovery signal.

Synes captures experimental attempts in a structured format and makes them searchable across similar research contexts — turning dead ends into direction.

Structured experiment database
Every attempt logged with parameters, outcomes, and metadata
Semantic search across experiments
Find related work by condition, parameter range, or research goal
Pattern-driven insights
Surface hidden signals across failed and partial experiments
Search
Filters:
pH: 6.5–7.5
Any outcome
2020–2025
14 experiments found across 6 datasets
Protein fold B — buffer PBS, pH 7.4
98% match
Outcome: Success (82% yield) Temp: 37°C Group: Lab A
Protein fold A — acetate buffer, pH 6.8
74% match
Outcome: Failed (18% yield) Temp: 37°C Group: Lab A
Fold variant — MES buffer, pH 6.5
61% match
Outcome: Partial (54%) Temp: 35°C Group: Lab C
Synes Insight
pH > 7.2 correlates with 3.4× higher yield across all matched experiments. Consider PBS buffer at 7.4.

Three steps to smarter experiments.

1
Log experiments
Capture experimental inputs, parameters, and outcomes in a structured, searchable format.
Exp #EX-042 pH 7.4
Buffer: PBS 50 mM
Outcome logged 82% yield
2
Search similar experiments
Find related experiments across datasets by condition, parameter range, or research goal.
✓ #EX-041 — pH 7.4, 82% yield (98% match)
#EX-040 — pH 6.8, failed (74% match)
14 experiments found across 6 datasets
3
Design better experiments
Learn from prior attempts to avoid redundant work and focus resources on high-yield conditions.
Recommendation: Use PBS at pH 7.4
Avoid: Acetate buffer pH < 7.0 (3× failure rate)
Next step: Vary temp 36–38°C
Get Started Free Try the Demo

Built for the people doing the science.

Synes fits the way research actually works — from academic discovery to commercial development.

🔬
Academic Research Labs
Stop repeating work across rotations. Give every student and postdoc access to the lab's full experimental history before they design their next run.
Universities
Core facilities
PI labs
🧬
Biotech Startups
Move faster with a full record of what's been tried. Reduce costly iteration cycles and focus R&D effort where it actually compounds.
Drug discovery
Genomics
Diagnostics
📊
Scientific Discovery Teams
Connect experimental knowledge across teams and time. Surface patterns that no single researcher could see from inside their own dataset.
Pharma R&D
Materials science
Agri-tech

Building better memory for experimental science.

Scientific research produces far more knowledge than what ultimately appears in a paper, protocol, or formal record. The reasoning behind an experiment — what was tried, what changed, why a decision was made, what failed, and what was learned along the way — is often distributed across notebooks, files, messages, meetings, and individual researchers.

That context is especially valuable because experimental work is inherently iterative. Researchers rarely move directly from hypothesis to result. They troubleshoot, modify parameters, compare prior attempts, revisit old decisions, and rely heavily on knowledge accumulated by the people around them. Yet most research software is designed to store records rather than preserve this evolving history in a form that can be easily recovered and reused.

Synes is exploring how experimental context can be captured, structured, and connected as research happens. The goal is to create a persistent memory of a team's work: one that helps researchers understand how an experiment evolved, identify relevant prior attempts, recover the reasoning behind past decisions, and carry that knowledge forward into future work.

Our research currently focuses on four areas
01
Experimental Memory
How to preserve experimental history — including attempts, modifications, outcomes, and reasoning — without adding significant burden to the researcher.
02
Cross-Experiment Relationships
How to represent and connect related experiments so that changes in parameters, methods, outcomes, and decisions can be understood across time rather than as isolated records.
03
Scientific Retrieval
How to surface the right prior context when it becomes relevant, particularly when a researcher is troubleshooting, revisiting a previous approach, or designing a new experiment.
04
Research Intelligence
How accumulated experimental history can support better scientific decisions by helping teams recognize patterns, compare prior work, and make more informed choices about what to try next.
same buffer batch 37 °C → 42 °C no amplification Exp 05 Exp 01 Exp 02 Exp 03 Exp 04 Exp 06 Exp 07 Shared parameter Modification Outcome Decision
Exp 05 inherits a buffer batch, a temperature change, and a failed run from work that came before it.
Scientific knowledge should compound as experiments happen.

The people building Synes.

A small team working across research, engineering, and the wet lab.

Rahul Sondawle
Founder & CEO
Leads product, scientific strategy, customer development, and company direction. Background in biotechnology, experimental neuroscience, and computational modeling at Johns Hopkins.
Ivan Theratil
Co-Founder & Engineering
Leads systems architecture and engineering. Background in mechatronics, full-stack software, cloud infrastructure, and data systems, including experience at AWS.
Kaicheng Cao
Founding Engineer
Works on the technical development of Synes, including AI workflows, retrieval systems, and experimental-memory infrastructure.
Lena Do
Product & BioOps
Works across researcher workflows, customer discovery, product development, and translating wet-lab needs into product requirements.

Research moves forward. Its memory should too.

Modern research teams generate an enormous amount of knowledge through everyday experimentation. Much of that knowledge never becomes a formal result. It lives in the adjustment someone made after an experiment failed, the explanation given during a lab meeting, the parameter change written in the margin of a notebook, or the experience a researcher develops after months of working on the same problem.

Over time, this context becomes fragmented. Projects evolve, protocols change, researchers graduate or move on, and teams are left reconstructing decisions from incomplete records and individual memory. The data may still exist, but the understanding around it often does not.

Synes was started around a simple idea: a research team should not have to rediscover what it has already learned.

We are building a persistent memory layer for experimental research that helps teams preserve the context behind their work, connect related experiments and decisions, and make that knowledge available to the people who need it later.

Synes is not intended to replace the tools researchers already use to record experiments or store data. Instead, it sits across that fragmented history and helps make the knowledge within it easier to recover, understand, and reuse.

Our long-term aim is to make research more cumulative at the team level: when one researcher learns something, that understanding should remain useful to the next researcher, the next experiment, and the next project.

Experiment Learn Remember Build forward
Our mission
Make scientific knowledge compound.

Get in touch

Interested in Synes, collaborating with us, or learning more about what we're building? We'd be glad to hear from you.

We usually reply within a couple of days. You can also write to us directly at team@synes.one.

Build better experiments faster.

Start exploring experimental knowledge with Synes.